Ga-68-Trivehexin

68Ga-Trivehexin is a radiotracer for positron emission tomography (PET) It is obtained by labeling the peptide conjugate Trivehexin with the positron emitting radionuclide gallium-68 (68Ga) The biological target of 68Ga-trive hexin is the cell surface receptor αvβ6-integrin. In early-stage cancer, TGF-β1 acts as a tumor suppressor but can turn into a tumor promoter as cancers develop, and furthermore induces fibrosis, particularly of the lung. The radioactive atom, galliam-68, decays with a half-life of approximately 68 min to the stable isotope zinc- 68 (68Zn) It can not be manufactured long before use, and 68Ga has to be introduced into the molecule before application. This process is referred to as the trivalent cation cation (TCC) cation transfer. It is usually obtained from a dedicated mobile radiolabeling source, a Gallium- 68 generator, in form of a dilute solution in dilute HCl.