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Southwest Garden is a historic neighborhood in St. Louis, Missouri, located south of The Hill and Forest Park Southeast, west of the Missouri Botanical Garden, east of Lindenwood Park, and north of North Hampton. It is bisected by Kingshighway Boulevard and named for its proximity to the Botanical Garden. The neighborhood features two National Historic Landmark Districts: Shaw’s Garden and Reber Place.

Shaw’s Garden, between Kingshighway and the Botanical Garden, was part of land once owned by Henry Shaw, the garden's founder. It is known for its well-preserved late 19th and early 20th-century multifamily buildings. Reber Place, west of Tower Grove Park, features a mix of frame homes, multifamily buildings, and bungalows from the same period.

Notable locations in the neighborhood include the St. Louis Psychiatric Rehabilitation Center, located on Arsenal Street, which operates on the former site of the St. Louis County Lunatic Asylum, designed by William Rumbold in 1869. Sublette Park, a neighborhood park with recreational facilities, is also present.

Southwest Garden's history dates back to 1769 when French settlers established the Prairie des Noyers Commons. The area was gradually developed in the 19th and early 20th centuries, influenced by Henry Shaw’s vision for the Botanical Garden and improvements in streetcar access. By the 1920s, the neighborhood was fully developed.

Demographically, as of 2020, Southwest Garden had a population that was 73.8% White, 13.1% Black, 4.7% Asian, 6.5% Two or More Races, and 1.8% Some Other Race, with 4.5% Hispanic or Latino.